Uptake of ketone bodies by rat brain in vivo
نویسندگان
چکیده
منابع مشابه
Effect of hyperphenylalaninaemia on lipid synthesis from ketone bodies by rat brain.
The effect of hyperphenylalaninaemia on the metabolism of ketone bodies in vivo and in vitro by developing rat brain was investigated. The incorporation in vivo of [14C]acetoacetate into cerebral lipids was decreased by both chronic (for 3 days) and acute (for 6h) hyperphenylalaninaemia induced by injecting phenylalanine into 1-week-old rats. In studies in vitro it was observed that the incorpo...
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Methylmalonate ( M M A ) is the principal metabolite which accumulates in tissues of patients affected by methylmalonic acidaemia. T h e disorder is caused by an inherited deficiency of 1.-methylmalonyl-CoA mutase ( E C S.4.YY.2) activity and is clinically characterized by severe acidosis and neurological dysfunction. Those who survive the earliest stages o f the disease present a variable degr...
متن کاملKetone-body utilization by adult and suckling rat brain in vivo.
1. Ketone-body utilization in fed and starved adult and suckling rats has been investigated by measuring arterio-venous differences across the brain. Venous blood was collected from the confluence of sinuses and arterial blood from the femoral artery in adult rats and by cardiac puncture in suckling rats. 2. During starvation the arterio-venous difference of ketone bodies increased in proportio...
متن کاملEffect of starvation and refeeding on amino acid uptake by mammary gland of the lactating rat. Role of ketone bodies.
Arteriovenous differences of amino acids across the mammary glands of lactating rats are diminished when the rats are starved for 24 h. When 24 h-starved rats were refed for 2 1/2 h, the arteriovenous differences of amino acids returned to values similar to those found in well-fed rats. In order to find a possible explanation for these rapid changes, we tested the effect of ketone bodies on ami...
متن کاملUtilization of ketone bodies by mammalian tissues.
It is now well established that ketone bodies (acetoacetate and D-3-hydroxybutyrate) are metabolized by many mammalian tissues and that the rate of utilization is mainly dependent on their availability in the circulation. The aim in this contribution is to summarize briefly the pathways of ketone-body metabolism and to discuss the role of ketone bodies m various tissues. For a detailed review o...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1971
ISSN: 0306-3283
DOI: 10.1042/bj1210017pa